Boehringer Ingelheim and CDR-Life Expand Collaboration Efforts with Global Licensing Agreement for CDR111, an Antibody-Based Trispecific M-gager® for Autoimmune Diseases

INGELHEIM, Germany and ZURICH, Switzerland–(BUSINESS WIRE)–Boehringer Ingelheim and CDR-Life, Inc. today announced a new global licensing agreement to develop CDR-Life’s unique antibody-based molecule CDR111 for autoimmune diseases. CDR111 is a trispecific M-gager^®, an antibody-based T-cell engager designed to selectively target and deplete B cells, with the goal of achieving immune system reset.

“Our expanded collaboration with Boehringer underscores the growing recognition of our platform’s ability to design high quality biologics that may translate into meaningful therapeutic advances,” said Christian Leisner, PhD, Chief Executive Officer of CDR-Life. “Having already demonstrated encouraging clinical progress together in GA, this new agreement further validates the versatility of our T-cell engager technology, and we are excited to see Boehringer advance CDR111 toward the clinic.”

“We are excited to expand upon our work with CDR-Life and apply their trispecific M-gager approach to autoimmune and inflammatory diseases with high unmet need, further broadening our differentiated pipeline,” said Carine Boustany, US Innovation Unit Site Head and Global Head of Immunology and Respiratory Diseases at Boehringer Ingelheim. “We see strong potential for CDR111 to demonstrate a deep and durable immune reset that may deliver transformative options for patients living with serious autoimmune disease.”

Under the terms of the agreement, CDR-Life is eligible for up to a total of CHF 456 million (approximately USD 570 million) in payments including CHF 38 million (approximately USD 48 million) in upfront and near-term payments, plus tiered royalties on future sales.