Kuros Biosciences announces publication of data on MagnetOs in eCM Journal linking MOA to enhanced predictable bone regeneration

Schlieren (Zurich), Switzerland, 22, 2021 – Kuros Biosciences (SIX: KURN) today announced the publication of new data in eCM Journal, a peer-reviewed publication focusing on preclinical re-search in the musculoskeletal field, on the mechanism of action of its MagnetOs bone graft.

The paper describes how immunomodulation by bone grafts with submicron topographical fea-tures translates to enhanced bone regeneration and successful spinal fusion. This is the first and only fully-translational peer-reviewed article for a bone graft material, describing evidence of its performance from benchtop to the clinic.

Joost de Bruijn, Chief Executive Officer of Kuros, said: “This first peer-reviewed publication in-cluding real-life clinical data with MagnetOs outlines how our product can make a significant difference to patients by delivering uniform, stable and reliable bone fusions.”

“Previous bone grafts have been supported by pre-clinical data which have not translated to the equivalent clinical experience, driving skepticism amongst spine surgeons about the efficacy of synthetic products. This article in eCM Journal clearly outlines the excellent efficacy of Magne-tOs in both preclinical and clinical studies. It particularly highlights MagnetOs’ submicron sur-face structure, which is designed to direct early wound healing toward a bone-forming pathway to support predictable healing and reliable fusion.”

Kuros helps patients live fuller, more active lives by giving surgeons the technology they need to eliminate non-unions. MagnetOs bone graft achieves this with a unique surface design proven to unlock the untapped power of the body’s immune system by growing new bone throughout the graft – for more predictable fusions. The eCM Journal article highlighted the following key points:

  • Evidence that submicron needle-shaped surface features accelerate osteoinduction by calcium phosphate in vivo
  • In vitro studies demonstrating that upregulation of pro-healing M2 macrophages occurs on submicron needle-shaped topography
  • An in vivo study demonstrating that M2 macrophage upregulation by submicron needle-shaped topography precedes osteoinductive bone formation
  • In vivo studies of calcium phosphate with submicron topography in clinically-relevant spi-nal fusion models, demonstrating equivalence with autograft and superiority to other synthetic bone grafts
  • Results of a clinical study in a in real-life cohort, in which calcium phosphate with submi-cron topography was successfully used in 52 lumbar and 25 cervical fusion patients, reaching 12-month fusion rates of 97% and 94% of treated levels, respectively.

For the full article in eCM Journal, click here.